| Start: Depart Juarez [Ciudad Juárez], Chihuahua, Mexico on Anahuac (North) | 0.3 |
| 1: Turn LEFT (West) onto Avenida 16 de Septiembre | 0.6 |
| 2: Turn RIGHT (North) onto Avenida Benito Juarez | 0.6 |
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| 3: Entering Texas | |
| 4: Road name changes to US-62 [US-85] | 0.5 |
| 5: Turn RIGHT to stay on US-62 [US-85] | 0.2 |
| 6: Keep STRAIGHT onto US-62 [E Paisano Dr] | 2.1 |
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| 7: Keep RIGHT onto Ramp towards I-10 / US-54 / Juarez | 0.2 |
| 8: Keep LEFT to stay on Ramp | < 0.1 |
| 9: Keep STRAIGHT onto Local road(s) | < 0.1 |
| 10: Turn LEFT (North) onto Ramp | < 0.1 |
| 11: Bear RIGHT (North-East) onto Local road(s) | < 0.1 |
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| 12: Take Ramp (LEFT) onto I-110 towards US-54 E / I-10 / US-180 | 0.3 |
| 13: Turn off onto Ramp | 0.2 |
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| 14: At exit 21A, take Ramp onto I-10 [US-180] towards I-10 / US-180 / Van Horn | 164.4 |
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| 15: Take Ramp (LEFT) onto I-20 [US-80] towards I-20 / FT Worth / Dallas | 421.0 |
| 16: Keep LEFT onto I-30 [US-80] towards I-30 / Downtown FT Worth | 361.8 |
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| 18: Interchange Reconstruction near Hope (NB) (September 1, 2009 - February 19, 2010) | |
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| 19: At exit 138A, take Ramp (RIGHT) onto I-440 towards I-440 / L.R. Natl. Airport / L.R. River Port / Memphis | 10.0 |
| 20: At exit 11, turn RIGHT onto Ramp towards I-40 / Memphis / Fort Smith | 0.3 |
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| 21: Take Ramp (RIGHT) onto I-40 towards I-40 / Memphis | 139.7 |
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| 23: At exit 12C, take Ramp (LEFT) onto I-40 towards I-40 / Nashville | 200.6 |
| 24: Merge onto I-24 [I-40] | 1.8 |
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| 25: Keep LEFT onto I-40 towards I-40 / Airport / Knoxville | 208.3 |
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| 26: At exit 421, take Ramp (LEFT) onto I-81 [Troy a McGill Memorial Hwy] towards I-81 / Bristol | 149.1 |
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| 28: Road name changes to I-77 [I-81] | 5.7 |
| 29: Stay on I-77 [I-81] | 2.3 |
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| 30: At exit 81, road name changes to I-81 [US-11] towards I-81 / US-11 / Roanoke | 110.2 |
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| 31: Merge onto I-64 [I-81] | 29.8 |
| 32: At exit 221, road name changes to I-81 towards I-81 / Winchester | 229.6 |
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| 33: Entering West Virginia | |
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| 34: Bridge work near Marlowe (EB) (November 29, 2009 - June 28, 2011) | |
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| 36: Entering Pennsylvania | |
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| 37: At exit 89, take Ramp (RIGHT) onto I-78 towards I-78 / Allentown | 125.6 |
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| 39: Resurfacing between Watchung and Millburn (NB) (October 10, 2008 - February 26, 2010) | |
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| 40: Keep LEFT onto I-78 Express Ln towards I-78 / I-95 / New Jersey Turnpike / Holland Tunnel / New York City | 8.8 |
| 41: Keep RIGHT onto I-78 towards I-95 / US-1-9 / New Jersey Turnpike / Port Newark | 1.4 |
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| 42: *Toll road* Stay on I-78 [New Jersey Tpke Ext] (East) towards I-78 / Exits 14A-14B-14C / Holland Tunnel | 8.1 |
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| 43: Road name changes to 12th St | 0.3 |
| 44: Road name changes to Boyle Plaza | 0.1 |
| 45: *Tollbooth* Road name changes to Holland Tunnel | 2.0 |
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| 47: At exit 3, take Ramp (RIGHT) onto Beach St [Ericsson St] towards Brooklyn | 0.1 |
| 48: Road name changes to Walker St | 0.2 |
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| 49: Turn RIGHT (South) onto Broadway | 0.3 |
| End: Arrive Manhattan (borough), New York, New York, United States | |
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