| Start: Depart 611 Mallard Creek Rd, Louisville, KY 40207 on Mallard Creek Rd (South-East) | 0.2 |
| 1: Turn RIGHT (East) onto Bowling Blvd | 0.8 |
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| 2: Turn RIGHT (East) onto US-60 Truck [Shelbyville Rd] | 0.3 |
| 3: Keep RIGHT onto Ramp towards I-264 / Watterson Expressway | 0.5 |
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| 4: At exit 19B, keep LEFT to stay on Ramp towards I-64 / Lexington | 0.2 |
| 5: At exit 19A, keep RIGHT to stay on Ramp towards I-64 | 0.6 |
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| 6: At exit 12B, take Ramp (RIGHT) onto I-64 | 237.6 |
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| 7: Rehabilitation near Graefenburg (EB) (October 8, 2007 - June 30, 2011) | |
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| 8: Reconstruction near Owingsville (EB) (November 1, 2006 - November 16, 2009) | |
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| 9: Entering West Virginia | |
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| 10: Resurfacing between South Charleston and Charleston (EB) (August 18, 2008 - November 13, 2009) | |
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| 11: At exit 59, take Ramp [59] onto I-64 [I-77] towards I-64 / I-77 / Beckley | 0.3 |
| 12: *Toll road* Stay on I-64 [I-77] (South) | 60.1 |
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| 13: Keep LEFT to stay on I-64 towards I-64 / Lewisburg | 152.3 |
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| 15: At exit 221, take Ramp (RIGHT) onto I-64 towards I-64 / Richmond | 103.1 |
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| 16: At exit 75, road name changes to I-95 [Richmond-Petersburg Tpke] towards I-95 / Thru Traffic | 6.1 |
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| 17: At exit 69, turn RIGHT onto Ramp towards VA-161 / Bells Road | 0.4 |
| 18: Take Ramp (RIGHT) onto SR-161 [E Commerce Rd] | 0.2 |
| 19: Turn LEFT (West) onto SR-161 [Bells Rd] | 1.2 |
| 20: Turn RIGHT (North) onto US-1 [US-301] | 0.1 |
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| End: Arrive 3625 Jefferson Davis Hwy, Richmond, VA 23234 | |
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