| Start: Depart Saskatoon, Saskatchewan, Canada on Local road(s) (West) | < 0.1 |
| 1: Turn LEFT (South) onto Spadina Crescent E | 1.0 |
| 2: Keep LEFT onto Local road(s) | 0.3 |
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| 3: Bear RIGHT (South-West) onto Local road(s) | 0.1 |
| 4: Bear RIGHT (West) onto Ramp, then immediately bear RIGHT (North-East) onto Spadina Crescent E towards University Bridge | 0.2 |
| 5: Bear RIGHT (South-East) onto Hwy-5 [25th St E] | 2.6 |
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| 6: Take Ramp (RIGHT) onto TC-16 [Circle Dr] towards Hwy-16 / Circle Dr / Trans Canada Hwy East / Hwy-11 S | 4.8 |
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| 7: Road name changes to TC-11 [TC-16] | 0.2 |
| 8: Road name changes to Hwy-11 [Louis Riel Trail] | 243.1 |
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| 9: Keep STRAIGHT onto Ramp towards Hwy-6 / Albert St | 0.5 |
| 10: Road name changes to Hwy-11 [Hwy-6] | 1.2 |
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| 11: Take Ramp (RIGHT) onto Hwy-11 [Ring Rd] towards Hwy-6 / Ring Road East / Hwy-1 | 7.5 |
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| 12: Road name changes to TC-1 | 7.2 |
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| 13: Keep RIGHT onto Ramp towards Hwy-6 / Weyburn | 0.3 |
| 14: Bear RIGHT (South) onto Hwy-6 [TC-1] | 38.3 |
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| 15: Bear LEFT (South) onto Hwy-39 [Hwy-6] | 157.4 |
| 16: Keep STRAIGHT onto Hwy-18 [Hwy-39] | 11.3 |
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| 17: Keep STRAIGHT onto Hwy-39 | 26.9 |
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| 18: Entering North Dakota | |
| 19: Road name changes to US-52 [Railway Ave] | 12.0 |
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| 20: Turn LEFT (East) onto US-52 [SR-5] | 119.2 |
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| 21: Keep LEFT onto Ramp towards US-2 / US-52 | 1.3 |
| 22: Bear RIGHT (South) onto US-2 [US-52] | 6.0 |
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| 23: Road name changes to US-2 Byp [US-52 Byp] | 2.0 |
| 24: Road name changes to US-2 [US-52] | 15.3 |
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| 25: Keep RIGHT onto Ramp towards US-52 / US-52 Business / Minot / Jamestown | 0.6 |
| 26: Turn RIGHT (South-East) onto US-52 | 161.4 |
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| 27: Turn LEFT (East) onto US-52 [SR-200] | 38.5 |
| 28: Turn RIGHT (South) onto US-281 [US-52] | 65.4 |
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| 29: Turn RIGHT (West) onto US-281 Truck [US-52 Truck] | 5.7 |
| 30: Take Ramp (LEFT) onto I-94 [US-281 Truck] towards I-94 / US-281-Truck / US-52-Truck / Fargo | 504.1 |
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| 32: At exit 216, road name changes to I-694 [I-94] towards I-94 / I-694 | 30.4 |
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| 33: Road name changes to I-35E [I-694] | 1.4 |
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| 34: Keep RIGHT onto I-694 towards I-694 | 17.4 |
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| 35: Road name changes to I-494 [I-694] | 0.1 |
| 36: At exit 58B, turn RIGHT onto Ramp towards I-94 / Madison | 0.4 |
| 37: Take Ramp onto I-94 [US-12] | 251.9 |
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| 39: Reconstruction near Tomah (SB) (July 17, 2009 - November 30, 2009) | |
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| 40: Merge onto I-90 [I-94] | 102.3 |
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| 41: Road name changes to I-39 [I-90] | 131.0 |
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| 43: *Toll road* Stay on I-39 [I-90] (South) | 22.9 |
| 44: *Toll road* Road name changes to I-90 [Jane Addams Memorial Tollway] towards I-90 / Chicago | 99.4 |
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| 45: Stay on I-90 [Kennedy Expy E] (East) | 9.2 |
| 46: Take Ramp (LEFT) onto I-90 Express Ln [I-94 Express Ln] towards Armitage Ave / Express Lanes | 10.5 |
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| 47: Take Ramp (LEFT) onto I-90 [I-94] towards I-90 / I-94 / Ryan Expy / Indiana | 6.8 |
| 48: Keep LEFT onto I-90 Express Ln [I-94 Express Ln] towards I-90-Express / I-94-Express / Garfield Blvd | 6.3 |
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| 49: Take Ramp onto I-90 [I-94] towards I-90 / Skyway / Indiana Toll Rd | 13.7 |
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| 50: Entering Indiana | |
| 51: *Toll road* Stay on I-90 [Indiana East-West] (South) | 33.7 |
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| 52: *Toll road* Road name changes to I-80 [I-90] | 416.3 |
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| 53: Entering Ohio | |
| 54: *Toll road* Stay on I-80 [I-90] | 153.0 |
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| 55: At exit 218, turn RIGHT onto Ramp towards I-80 | 1.5 |
| 56: Keep LEFT to stay on Ramp towards I-80 / CR-18 / Youngstown / Mahoning Ave | 0.4 |
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| 57: Take Ramp (LEFT) onto I-80 towards I-80 / Youngstown | 614.7 |
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| 58: Entering Pennsylvania | |
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| 60: Construction between Parsippany and Landing (EB) (September 1, 2009 - March 31, 2010) | |
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| 61: At exit 53, take Ramp (RIGHT) onto US-46 towards US-46 / RT-3 / Meadowlands Sports Complex / Wayne / Clifton / Lincoln Tunnel | 6.8 |
| 62: Keep RIGHT onto SR-3 towards RT-3 / Garden State Parkway South / New Jersey Turnpike / Lincoln Tunnel | 15.1 |
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| 63: Road name changes to SR-3 Express Ln | 1.4 |
| 64: Take Ramp (LEFT) onto SR-495 towards RT-495 / Lincoln Tunnel | 2.4 |
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| 65: Turn RIGHT onto Ramp towards Weehawken / Hoboken | 0.2 |
| 66: Take Ramp (LEFT) onto SR-495 towards RT-495 / Lincoln Tunnel | 1.2 |
| 67: Take Ramp (LEFT) onto SR-495 [Lincoln Tunnel Reversible Ln] | 2.7 |
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| 69: Turn LEFT onto Ramp towards 40 St and North / West Side Hwy | 0.1 |
| 70: Turn LEFT (North) onto Dyer Ave | 0.2 |
| 71: Turn LEFT (West) onto W 42nd St | 0.7 |
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| 72: Turn RIGHT (North-East) onto SR-9A [12th Ave] | 2.8 |
| 73: Turn RIGHT onto Ramp towards W 79 St | 0.2 |
| 74: Bear RIGHT (East) onto W 79th St | 0.4 |
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| 75: Turn LEFT (North) onto Amsterdam Ave | 0.2 |
| 76: Turn RIGHT (East) onto W 81st St | 0.2 |
| End: Arrive 129 W 81st St, New York, NY 10024 | |
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