| Start: Depart US Military Academy (college), New York on Local road(s) (South) | 0.6 |
| 1: Bear LEFT (South) onto Howard Rd | 0.3 |
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| 2: Turn RIGHT (West) onto Ruger Rd | 0.4 |
| 3: Bear RIGHT (North-West) onto Washington Rd | 0.6 |
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| 4: Keep STRAIGHT onto Washington Rd [West Point Hwy] | 0.4 |
| 5: Bear LEFT (South-West) onto SR-218 | 1.1 |
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| 6: Bear RIGHT (South) onto SR-218 [SR-293] | 0.1 |
| 7: Road name changes to SR-293 | 6.8 |
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| 8: Keep STRAIGHT onto US-6 | 2.8 |
| 9: Keep RIGHT onto Ramp towards RT-17 / RT-32 / Suffern / Newburgh | 0.3 |
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| 10: Turn RIGHT (North-East) onto SR-17 | 0.2 |
| 11: Take Ramp (RIGHT) onto SR-17 towards I-87 / New York Thruway | 0.5 |
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| 12: Turn RIGHT onto Ramp towards I-87 / New York | 0.5 |
| 13: *Toll road* Merge onto I-87 [Gov Thomas E Dewey Thruway] | 0.1 |
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| 14: Stay on I-87 [Gov Thomas E Dewey Thruway] (South-West) | 14.1 |
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| 15: At exit 15, take Ramp (RIGHT) onto I-287 [SR-17] towards I-287 / RT-17 / New Jersey | 47.0 |
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| 17: At exit 21B, take Ramp (RIGHT) onto I-78 towards I-78 / Easton Pa | 107.4 |
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| 18: Entering Pennsylvania | |
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| 19: Take Ramp (LEFT) onto I-81 [American Legion Memorial Hwy] towards I-81 / Harrisburg | 230.3 |
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| 21: Entering West Virginia | |
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| 23: Road name changes to I-64 [I-81] | 29.7 |
| 24: At exit 191, keep LEFT onto I-81 towards I-81 / Roanoke | 110.8 |
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| 25: Road name changes to I-77 [I-81] | 7.6 |
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| 26: At exit 72, road name changes to I-81 [US-52] towards I-81 / US-52 / Bristol | 148.3 |
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| 28: Take Ramp (RIGHT) onto I-40 towards I-40 / Knoxville | 53.5 |
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| 29: Bridge work near Knoxville (WB) (May 9, 2008 - November 30, 2009) | |
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| 30: Keep LEFT onto I-75 towards I-75 / Chattanooga | 83.4 |
| 31: At exit 2, take Ramp (RIGHT) onto I-24 towards I-24 / I-59 / Chattanooga / Birmingham | 17.3 |
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| 33: At exit 167, take Ramp (LEFT) onto I-59 towards I-59 / Birmingham | 124.1 |
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| 35: At exit 137, take Ramp (LEFT) onto I-459 towards I-459 / Tuscaloosa / Montgomery | 33.2 |
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| 36: Interchange Reconstruction near Hoover (WB) (October 9, 2009 - May 28, 2010) | |
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| 37: Take Ramp (LEFT) onto I-20 [I-59] towards I-20 / I-59 / Tuscaloosa | 130.0 |
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| 38: Resurfacing near Tuscaloosa (WB) (October 5, 2007 - November 13, 2009) | |
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| 40: Keep LEFT onto I-59 towards I-59 / Laurel / New Orleans | 83.2 |
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| 41: Construction near Laurel (WB) (October 6, 2008 - November 30, 2009) | |
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| 42: Resurfacing in Moselle (SB) (July 1, 2009 - November 30, 2009) | |
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| 43: At exit 65, turn RIGHT onto Ramp towards US-98 / Hardy St / Columbia | 0.2 |
| 44: Keep LEFT to stay on Ramp towards Hardy St. / University of Southern Miss | < 0.1 |
| 45: Bear LEFT (South) onto Local road(s) | < 0.1 |
| 46: Turn LEFT (East) onto SR-198 [Hardy St] | 1.1 |
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| 47: Keep STRAIGHT onto SR-198 [W Hardy St] | 0.1 |
| 48: Turn LEFT (North) onto W Memorial Dr | 0.2 |
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| End: Arrive College Dr, Hattiesburg, MS 39401 | |
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