| Start: Depart Saint Louis University [St. Louis University] (college), St. Louis, Missouri on Local road(s) (East) | < 0.1 |
| 1: Turn RIGHT (South) onto (N) Grand Blvd | 1.4 |
| 2: Take Ramp (LEFT) onto I-44 towards I-44 | 1.3 |
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| 3: At exit 290A, take Ramp (RIGHT) onto I-55 towards I-55 / Memphis | 274.0 |
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| 4: Construction between Mehlville and St. Louis (SB) (August 31, 2009 - March 31, 2010) | |
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| 6: Merge onto I-40 [I-55] | 2.2 |
| 7: Keep RIGHT onto I-55 [US-61] towards I-55 / Memphis / Jackson MS | 5.2 |
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| 9: Take Ramp (RIGHT) onto I-55 towards I-55 / Airport / Jackson Miss | 5.7 |
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| 10: Construction near Memphis (EB) (December 1, 2008 - December 15, 2010) | |
| 11: Take Ramp (RIGHT) onto I-55 towards I-55 / Jackson Miss | 202.7 |
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| 12: Reconstruction near Memphis (SB) (August 1, 2009 - December 15, 2009) | |
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| 14: At exit 94, turn RIGHT onto Ramp towards I-20 / US-49 / Meridian / Hattiesburg / Airport | 0.9 |
| 15: Take Ramp (RIGHT) onto US-49 towards US-49 / Richland / Hattiesburg | 85.3 |
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| 16: Turn RIGHT (West) onto Local road(s) | < 0.1 |
| 17: Turn LEFT (South) onto Championship Ln | 0.1 |
| 18: Turn RIGHT (West) onto College Dr | 0.2 |
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| End: Arrive College Dr, Hattiesburg, MS 39401 | |
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