| Start: Depart East Carolina University (college), Greenville, North Carolina on Alumni Circle (West) | 0.1 |
| 1: Turn LEFT (West) onto Faculty Way | 0.2 |
| 2: Turn LEFT (North) onto Trustees Way, then immediately turn LEFT (West) onto (E) 5th St | 0.3 |
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| 3: Road name changes to (W) 5th St [Martin Luther King Dr] | 0.4 |
| 4: Turn RIGHT to stay on W 5th St [Martin Luther King Dr] | 0.7 |
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| 5: Keep STRAIGHT onto (W) 5th St | < 0.1 |
| 6: Turn LEFT (South) onto US-13 [SR-11] | 0.3 |
| 7: Bear RIGHT (West) onto Stantonsburg Rd | 2.5 |
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| 8: Road name changes to Local road(s) | 0.3 |
| 9: Road name changes to US-264 [John P East Fwy] | 32.5 |
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| 10: Road name changes to I-795 [US-264] | 2.6 |
| 11: At exit 40, turn RIGHT onto Ramp towards NC-42 / Wilson / Clayton | 0.2 |
| 12: Turn RIGHT (West) onto SR-42 | 2.8 |
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| 13: Take Ramp (LEFT) onto I-95 towards I-95 | 154.1 |
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| 14: Entering South Carolina | |
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| 15: At exit 160B, take Ramp (RIGHT) onto I-20 [Strom Thurmond Fwy] towards I-20 / Columbia | 420.5 |
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| 17: Reconstruction between Grovetown and Augusta (WB) (October 31, 2008 - June 30, 2010) | |
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| 18: Rehabilitation near Lithonia (WB) (September 14, 2009 - February 26, 2010) | |
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| 20: At exit 136, turn RIGHT onto Ramp towards I-459 / Montgomery / Tuscaloosa / Gadsden | 0.3 |
| 21: Take Ramp (LEFT) onto I-459 towards I-459 / Montgomery / Tuscaloosa | 29.3 |
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| 22: Interchange Reconstruction near Hoover (WB) (October 9, 2009 - May 28, 2010) | |
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| 23: Take Ramp (LEFT) onto I-20 [I-59] towards I-20 / I-59 / Tuscaloosa | 130.0 |
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| 24: Resurfacing near Tuscaloosa (WB) (October 5, 2007 - February 12, 2010) | |
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| 26: Keep LEFT onto I-59 towards I-59 / Laurel / New Orleans | 83.2 |
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| 27: Construction near Laurel (WB) (October 6, 2008 - February 15, 2010) | |
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| 28: Resurfacing in Moselle (SB) (July 1, 2009 - February 26, 2010) | |
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| 29: At exit 65, turn RIGHT onto Ramp towards US-98 / Hardy St / Columbia | 0.2 |
| 30: Keep LEFT to stay on Ramp towards Hardy St. / University of Southern Miss | < 0.1 |
| 31: Bear LEFT (South) onto Local road(s) | < 0.1 |
| 32: Turn LEFT (East) onto SR-198 [Hardy St] | 1.1 |
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| 33: Keep STRAIGHT onto SR-198 [W Hardy St] | 0.1 |
| 34: Turn LEFT (North) onto W Memorial Dr | 0.2 |
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| End: Arrive College Dr, Hattiesburg, MS 39401 | |
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