| Start: Depart DePaul University (college), Chicago, Illinois on W Belden Ave (East) | 0.2 |
| 1: Turn RIGHT (South) onto N Halsted St | 2.6 |
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| 2: Turn LEFT (East) onto W Lake St, then immediately turn RIGHT (South) onto Ramp | 0.2 |
| 3: Merge onto I-90 [I-94] | 3.0 |
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| 4: Keep LEFT onto I-90 Express Ln [I-94 Express Ln] towards I-90-Express / I-94-Express / Garfield Blvd | 3.9 |
| 5: Road name changes to I-94 Express Ln [Dan Ryan Express Ln E] | 1.6 |
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| 6: Merge onto I-94 [Dan Ryan Expy E] | 3.4 |
| 7: At exit 63, turn RIGHT onto Ramp towards I-57 / Memphis | 0.1 |
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| 8: Take Ramp (LEFT) onto I-57 | 381.0 |
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| 9: Construction between Mattoon and Arcola (SB) (January 18, 2010 - October 29, 2010) | |
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| 11: At exit 1A, take Ramp (RIGHT) onto I-55 towards I-55 / Memphis | 132.2 |
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| 13: Merge onto I-40 [I-55] | 2.2 |
| 14: Keep RIGHT onto I-55 [US-61] towards I-55 / Memphis / Jackson MS | 5.2 |
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| 16: Take Ramp (RIGHT) onto I-55 towards I-55 / Airport / Jackson Miss | 5.7 |
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| 17: Construction near Memphis (EB) (December 1, 2008 - December 15, 2010) | |
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| 18: Take Ramp (RIGHT) onto I-55 towards I-55 / Jackson Miss | 202.7 |
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| 20: At exit 94, turn RIGHT onto Ramp towards I-20 / US-49 / Meridian / Hattiesburg / Airport | 0.9 |
| 21: Take Ramp (RIGHT) onto US-49 towards US-49 / Richland / Hattiesburg | 85.3 |
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| 22: Turn RIGHT (West) onto Local road(s) | < 0.1 |
| 23: Turn LEFT (South) onto Championship Ln | 0.1 |
| 24: Turn RIGHT (West) onto College Dr | 0.2 |
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| End: Arrive College Dr, Hattiesburg, MS 39401 | |
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