| Start: Depart Atlanta, Georgia, United States on Capitol Sq SW (East) | 0.1 |
| 1: Turn RIGHT (South) onto Capitol Ave (SE) [Capitol Ave SW], then immediately turn RIGHT (West) onto SR-154 [Memorial Dr SW] | 0.4 |
| 2: Turn LEFT (South) onto Pryor St SW | 0.2 |
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| 3: Take Ramp (RIGHT) onto I-20 [SR-402] towards I-20 | 134.0 |
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| 5: At exit 136, turn RIGHT onto Ramp towards I-459 / Montgomery / Tuscaloosa / Gadsden | 0.3 |
| 6: Take Ramp (LEFT) onto I-459 towards I-459 / Montgomery / Tuscaloosa | 29.3 |
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| 7: Interchange Reconstruction near Hoover (WB) (October 9, 2009 - May 28, 2010) | |
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| 8: Take Ramp (LEFT) onto I-20 [I-59] towards I-20 / I-59 / Tuscaloosa | 130.0 |
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| 9: Resurfacing near Tuscaloosa (WB) (October 5, 2007 - February 12, 2010) | |
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| 11: Keep LEFT onto I-59 towards I-59 / Laurel / New Orleans | 83.2 |
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| 12: Construction near Laurel (WB) (October 6, 2008 - February 15, 2010) | |
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| 13: Resurfacing in Moselle (SB) (July 1, 2009 - February 26, 2010) | |
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| 14: At exit 65, turn RIGHT onto Ramp towards US-98 / Hardy St / Columbia | 0.2 |
| 15: Keep LEFT to stay on Ramp towards Hardy St. / University of Southern Miss | < 0.1 |
| 16: Bear LEFT (South) onto Local road(s) | < 0.1 |
| 17: Turn LEFT (East) onto SR-198 [Hardy St] | 1.1 |
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| 18: Keep STRAIGHT onto SR-198 [W Hardy St] | 0.1 |
| 19: Turn LEFT (North) onto W Memorial Dr | 0.2 |
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| End: Arrive College Dr, Hattiesburg, MS 39401 | |
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