| Start: Depart 9201 University City Blvd, Charlotte, NC 28213 on SR-49 [University City Blvd] (South-West) | 1.9 |
| 1: Merge onto US-29 [SR-49] | 0.4 |
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| 2: Keep RIGHT onto Ramp towards I-85 S / Gastonia | 0.1 |
| 3: Road name changes to US-29 Byp | 0.4 |
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| 4: Take Ramp onto I-85 towards I-85 | 244.2 |
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| 5: Entering South Carolina | |
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| 7: Merge onto I-75 [I-85] | 3.1 |
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| 8: Interchange Reconstruction near Atlanta (SB) (February 1, 2008 - August 31, 2010) | |
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| 9: At exit 247, turn RIGHT onto Ramp towards I-20 / Augusta / Ralph D. Abernathy Fwy / Birmingham | 0.1 |
| 10: Take Ramp (RIGHT) onto I-20 [SR-402] towards I-20 / Birmingham | 134.5 |
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| 12: At exit 136, turn RIGHT onto Ramp towards I-459 / Montgomery / Tuscaloosa / Gadsden | 0.3 |
| 13: Take Ramp (LEFT) onto I-459 towards I-459 / Montgomery / Tuscaloosa | 29.3 |
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| 14: Interchange Reconstruction near Hoover (WB) (October 9, 2009 - May 28, 2010) | |
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| 15: Take Ramp (LEFT) onto I-20 [I-59] towards I-20 / I-59 / Tuscaloosa | 130.0 |
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| 16: Resurfacing near Tuscaloosa (WB) (October 5, 2007 - November 13, 2009) | |
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| 18: Keep LEFT onto I-59 towards I-59 / Laurel / New Orleans | 83.2 |
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| 19: Construction near Laurel (WB) (October 6, 2008 - November 30, 2009) | |
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| 20: Resurfacing in Moselle (SB) (July 1, 2009 - November 30, 2009) | |
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| 21: At exit 65, turn RIGHT onto Ramp towards US-98 / Hardy St / Columbia | 0.2 |
| 22: Keep LEFT to stay on Ramp towards Hardy St. / University of Southern Miss | < 0.1 |
| 23: Bear LEFT (South) onto Local road(s) | < 0.1 |
| 24: Turn LEFT (East) onto SR-198 [Hardy St] | 1.1 |
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| 25: Keep STRAIGHT onto SR-198 [W Hardy St] | 0.1 |
| 26: Turn LEFT (North) onto W Memorial Dr | 0.2 |
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| End: Arrive College Dr, Hattiesburg, MS 39401 | |
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