| Start: Depart 4800 Calhoun Rd, Houston, TX 77004 on University Dr (East) | 0.3 |
| 1: Turn LEFT (North) onto SR-5 Spur | < 0.1 |
| 2: Take Ramp (LEFT) onto SR-5 Spur towards I-45 N | 0.7 |
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| 3: Take Ramp (LEFT) onto I-45 [Gulf Fwy] towards I-45 / Dallas | 1.6 |
| 4: At exit 46A, take Ramp (RIGHT) onto US-59 [Eastex Fwy] towards US-59 / Cleveland | 1.5 |
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| 5: Keep RIGHT onto Ramp towards I-10 / San Antonio / Beaumont | 0.3 |
| 6: Take Ramp (LEFT) onto I-10 [US-90] towards I-10 / Beaumont | 270.2 |
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| 8: Bridge work near Lake Charles (NB) (October 10, 2008 - December 11, 2009) | |
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| 9: At exit 159, take Ramp (LEFT) onto I-12 [West Florida Republic Pkwy] towards I-12 / Hammond | 85.7 |
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| 10: Road widening near Baton Rouge (EB) (September 1, 2009 - February 29, 2012) | |
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| 11: Take Ramp (RIGHT) onto I-59 towards I-59 / Hattiesburg | 76.7 |
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| 13: At exit 65A-B, turn RIGHT onto Ramp towards US-98 / Hardy St / Columbia | 0.2 |
| 14: Take Ramp (RIGHT) onto SR-198 [Hardy St] towards Hardy St | 1.2 |
| 15: Keep STRAIGHT onto SR-198 [W Hardy St] | 0.1 |
| 16: Turn LEFT (North) onto W Memorial Dr | 0.2 |
| End: Arrive College Dr, Hattiesburg, MS 39401 | |
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